United States securities and exchange commission logo

                           February 5, 2024

       Alexander Cumbo
       Chief Executive Officer
       Solid Biosciences Inc.
       500 Rutherford Avenue, Third Floor
       Charlestown, MA 02129

                                                        Re: Solid Biosciences
Statement on Form S-3
                                                            Filed January 30,
                                                            File No. 333-276764

       Dear Alexander Cumbo:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jessica
Dickerson at 202-551-8013 with any questions.


                           Division of Corporation Finance

                           Office of Life Sciences
       cc:                                              Caroline Dotolo, Esq.