United States securities and exchange commission logo

                          March 18, 2021

       Ilan Ganot
       Chief Executive Officer
       Solid Biosciences Inc.
       141 Portland Street, Fifth Floor
       Cambridge, MA 02139

                                                        Re: Solid Biosciences
Statement on Form S-3
                                                            Filed March 15,
                                                            File No. 333-254310

       Dear Mr. Ganot:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Margaret
Schwartz at 202-551-7153 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Lia Der Marderosian,