United States securities and exchange commission logo March 18, 2021 Ilan Ganot Chief Executive Officer Solid Biosciences Inc. 141 Portland Street, Fifth Floor Cambridge, MA 02139 Re: Solid Biosciences Inc. Registration Statement on Form S-3 Filed March 15, 2021 File No. 333-254310 Dear Mr. Ganot: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Margaret Schwartz at 202-551-7153 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Lia Der Marderosian, Esq.