United States securities and exchange commission logo February 1, 2023 Alexander Cumbo Chief Executive Officer Solid Biosciences Inc. 500 Rutherford Avenue Charlestown, MA 02129 Re: Solid Biosciences Inc. Registration Statement on Form S-3 Filed January 26, 2023 File No. 333-269424 Dear Alexander Cumbo: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Tim Buchmiller at (202) 551-3635 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Caroline Dotolo, Esq.