00000 - Document - Template Link link:presentationLink link:calculationLink link:definitionLink 100000 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 100010 - Statement - Consolidated Balance Sheets link:calculationLink link:presentationLink link:definitionLink 100020 - Statement - Consolidated Balance Sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 100030 - Statement - Consolidated Statements of Operations link:calculationLink link:presentationLink link:definitionLink 100040 - Statement - Consolidated Statements of Comprehensive Loss link:calculationLink link:presentationLink link:definitionLink 100050 - Statement - Consolidated Statements of Stockholders' Equity link:calculationLink link:presentationLink link:definitionLink 100060 - Statement - Consolidated Statements of Stockholders' Equity (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 100070 - Statement - Consolidated Statements of Cash Flows link:calculationLink link:presentationLink link:definitionLink 100080 - Disclosure - Nature of the Business and Basis of Presentation link:calculationLink link:presentationLink link:definitionLink 100090 - Disclosure - Summary of Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 100100 - Disclosure - Collaborations link:calculationLink link:presentationLink link:definitionLink 100110 - Disclosure - Fair Value of Financial Assets and Liabilities link:calculationLink link:presentationLink link:definitionLink 100120 - Disclosure - Available-for-Sale Securities link:calculationLink link:presentationLink link:definitionLink 100130 - Disclosure - Prepaid Expenses and Other Current Assets link:calculationLink link:presentationLink link:definitionLink 100140 - Disclosure - Property and Equipment link:calculationLink link:presentationLink link:definitionLink 100150 - Disclosure - Accrued Expenses link:calculationLink link:presentationLink link:definitionLink 100160 - Disclosure - Equity-Based Compensation link:calculationLink link:presentationLink link:definitionLink 100170 - Disclosure - Leases link:calculationLink link:presentationLink link:definitionLink 100180 - Disclosure - Commitments and Contingencies link:calculationLink link:presentationLink link:definitionLink 100190 - Disclosure - License Agreements link:calculationLink link:presentationLink link:definitionLink 100200 - Disclosure - Net Loss per Share link:calculationLink link:presentationLink link:definitionLink 100210 - Disclosure - Income Taxes link:calculationLink link:presentationLink link:definitionLink 100220 - Disclosure - Defined Contribution Plan link:calculationLink link:presentationLink link:definitionLink 100230 - Disclosure - Restructuring link:calculationLink link:presentationLink link:definitionLink 100240 - Disclosure - Summary of Significant Accounting Policies (Policies) link:calculationLink link:presentationLink link:definitionLink 100250 - Disclosure - Summary of Significant Accounting Policies (Tables) link:calculationLink link:presentationLink link:definitionLink 100260 - Disclosure - Collaborations (Tables) link:calculationLink link:presentationLink link:definitionLink 100270 - Disclosure - Fair Value of Financial Assets and Liabilities (Tables) link:calculationLink link:presentationLink link:definitionLink 100280 - Disclosure - Available-for-Sale Securities (Tables) link:calculationLink link:presentationLink link:definitionLink 100290 - Disclosure - Prepaid Expenses and Other Current Assets (Tables) link:calculationLink link:presentationLink link:definitionLink 100300 - Disclosure - Property and Equipment (Tables) link:calculationLink link:presentationLink link:definitionLink 100310 - Disclosure - Accrued Expenses (Tables) link:calculationLink link:presentationLink link:definitionLink 100320 - Disclosure - Equity-Based Compensation (Tables) link:calculationLink link:presentationLink link:definitionLink 100330 - Disclosure - Leases (Tables) link:calculationLink link:presentationLink link:definitionLink 100340 - Disclosure - Net Loss per Share (Tables) link:calculationLink link:presentationLink link:definitionLink 100350 - Disclosure - Income Taxes (Tables) link:calculationLink link:presentationLink link:definitionLink 100360 - Disclosure - Restructuring (Tables) link:calculationLink link:presentationLink link:definitionLink 100370 - Disclosure - Nature of the Business and Basis of Presentation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100380 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100390 - Disclosure - Summary of Significant Accounting Policies - Reconciliation of Amounts From Cash Flow Statement to Balance Sheet (Detail) link:calculationLink link:presentationLink link:definitionLink 100400 - Disclosure - Collaborations - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100410 - Disclosure - Collaborations - Summary of Changes in Balances of Company's Related Party Collaboration Receivables and Contract Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 100420 - Disclosure - Fair Value of Financial Assets and Liabilities - Summary of Assets and Liabilities Measured at Fair Value on Recurring Basis and Indicate Level of Fair Value Hierarchy Utilized (Detail) link:calculationLink link:presentationLink link:definitionLink 100430 - Disclosure - Fair Value of Financial Assets and Liabilities - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100440 - Disclosure - Available-for-Sale Securities - Schedule of Fair Value of Available-for-Sale Debt Securities by Type of Security (Detail) link:calculationLink link:presentationLink link:definitionLink 100450 - Disclosure - Available-for-Sale Securities - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100460 - Disclosure - Available-for-Sale Securities - Summary Estimated Fair Value and Amortized Cost of Available-for-Sale Securities by Contractual Maturity (Detail) link:calculationLink link:presentationLink link:definitionLink 100470 - Disclosure - Prepaid Expenses and Other Current Assets - Schedule of Prepaid Expenses and Other Current Assets (Detail) link:calculationLink link:presentationLink link:definitionLink 100480 - Disclosure - Property and Equipment - Summary of Property and Equipment (Detail) link:calculationLink link:presentationLink link:definitionLink 100490 - Disclosure - Property and Equipment - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100500 - Disclosure - Accrued Expenses - Summary of Accrued Expenses and Other Current Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 100510 - Disclosure - Equity-Based Compensation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100520 - Disclosure - Equity-Based Compensation - Summary of Stock Option Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 100530 - Disclosure - Equity-Based Compensation - Assumptions for Measuring Fair Values of Stock Options (Detail) link:calculationLink link:presentationLink link:definitionLink 100540 - Disclosure - Equity-Based Compensation - Summary of Restricted Stock Unit Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 100550 - Disclosure - Equity-Based Compensation - Summary of Unvested Restricted Shares of Common Stock Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 100560 - Disclosure - Equity-Based Compensation - Schedule of Equity-based Compensation Expense (Detail) link:calculationLink link:presentationLink link:definitionLink 100570 - Disclosure - Leases - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100580 - Disclosure - Leases - Future Minimum Payments for Operating and Finance Leases (Detail) link:calculationLink link:presentationLink link:definitionLink 100590 - Disclosure - Leases - Future Minimum Payments for Operating and Finance Leases (Detail)2 link:calculationLink link:presentationLink link:definitionLink 100600 - Disclosure - Leases - Supplemental Disclosure of Cash Flow Information Related to Leases (Detail) link:calculationLink link:presentationLink link:definitionLink 100610 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100620 - Disclosure - License Agreements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100630 - Disclosure - Net Loss per Share - Schedule of Basic and Diluted Net Loss per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 100640 - Disclosure - Net Loss per Share - Schedule of Antidilutive Securities Excluded from Calculation of Diluted Net Loss per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 100650 - Disclosure - Income Taxes - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100660 - Disclosure - Income Taxes - Schedule of Reconciliation of Income Taxes Computed by U.S. Federal Statutory Rate (Detail) link:calculationLink link:presentationLink link:definitionLink 100670 - Disclosure - Income Taxes - Schedule of Net Deferred Tax Assets (Detail) link:calculationLink link:presentationLink link:definitionLink 100680 - Disclosure - Defined Contribution Plan - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100690 - Disclosure - Restructuring- Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100700 - Disclosure - Restructuring - Schedule of Total Amount Expected to be Incurred and Liability Related to Restructuring (Detail) link:calculationLink link:presentationLink link:definitionLink