Entity Central Index Key
Cover [Abstract]
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Title of 12(b) Security
Security12b Title
Security Exchange Name
Security Exchange Name
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity File Number
Entity File Number
Entity Tax Identification Number
Entity Tax Identification Number
Entity Incorporation, State or Country Code
Entity Incorporation State Country Code
Entity Address, Address Line One
Entity Address Address Line1
Entity Address, City or Town
Entity Address City Or Town
Entity Address, State or Province
Entity Address State Or Province
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Document Annual Report
Document Annual Report
Document Transition Report
Document Transition Report
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity Ex Transition Period
Entity Ex Transition Period
Entity Shell Company
Entity Shell Company
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Entity Public Float
Entity Public Float
Entity Well-known Seasoned Issuer
Entity Well Known Seasoned Issuer
Entity Voluntary Filers
Entity Voluntary Filers
Entity Current Reporting Status
Entity Current Reporting Status
Entity Interactive Data Current
Entity Interactive Data Current
ICFR Auditor Attestation Flag
Icfr Auditor Attestation Flag
Auditor Firm ID
Auditor Firm Id
Auditor Name
Auditor Name
Auditor Location
Auditor Location
Statement Of Financial Position [Abstract]
Assets
Assets [Abstract]
Current assets:
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Available-for-sale securities
Available For Sale Securities Debt Securities Current
Prepaid expenses and other current assets
Prepaid Expense And Other Assets Current
Accounts receivable - related party
Accounts Receivable Related Parties Current
Total current assets
Assets Current
Operating lease, right of use asset
Operating Lease Right Of Use Asset
Property and equipment, net
Property Plant And Equipment Net
Other non-current assets
Other Assets Noncurrent
Restricted cash
Restricted Cash Noncurrent
Total assets
Assets
Liabilities and Stockholders' Equity
Liabilities And Stockholders Equity [Abstract]
Current liabilities:
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Accrued expenses
Accrued Liabilities Current
Operating lease liabilities
Operating Lease Liability Current
Finance lease liabilities
Finance Lease Liability Current
Deferred revenue - related party
Contract With Customer Liability Current
Other current liabilities
Other Liabilities Current
Total current liabilities
Liabilities Current
Operating lease liabilities, excluding current portion
Operating Lease Liability Noncurrent
Finance lease obligations, excluding current portion
Finance Lease Liability Noncurrent
Deferred revenue - related party, excluding current portion
Contract With Customer Liability Noncurrent
Other non-current liabilities
Other Liabilities Noncurrent
Total liabilities
Liabilities
Commitments and Contingencies (Note 11)
Commitments And Contingencies
Stockholders’ Equity:
Stockholders Equity [Abstract]
Preferred stock, $0.001 par value; 10,000,000 shares authorized at December 31, 2021 and December 31, 2020; no shares issued and outstanding at December 31, 2021 and December 31, 2020
Preferred Stock Value
Common stock, $0.001 par value; 300,000,000 shares authorized at December 31, 2021 and December 31, 2020; 110,340,281 shares issued and outstanding at December 31, 2021 and 84,893,994 shares issued and outstanding at December 31, 2020; 2,158,329 pre-funded warrants outstanding at December 31, 2021 and December 31, 2020
Common Stock Value
Additional paid-in capital
Additional Paid In Capital Common Stock
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income Loss Net Of Tax
Accumulated deficit
Retained Earnings Accumulated Deficit
Total stockholders' equity
Stockholders Equity
Total liabilities and stockholders' equity
Liabilities And Stockholders Equity
Pre-funded warrants outstanding.
Preferred stock, par value
Preferred Stock Par Or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock Shares Authorized
Preferred stock, shares issued
Preferred Stock Shares Issued
Preferred stock, shares outstanding
Preferred Stock Shares Outstanding
Common stock, par value
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares issued
Common Stock Shares Issued
Common stock, shares outstanding
Common Stock Shares Outstanding
Pre-funded warrants outstanding
Pre Funded Warrants Outstanding
Income Statement [Abstract]
Revenue
Revenues
Operating expenses:
Operating Expenses [Abstract]
Research and development
Research And Development Expense
General and administrative
General And Administrative Expense
Restructuring expense
Restructuring Charges
Total operating expenses
Operating Expenses
Loss from operations
Operating Income Loss
Other income, net:
Nonoperating Income Expense [Abstract]
Interest income, net
Investment Income Interest
Other income
Other Nonoperating Income Expense
Total other income, net
Nonoperating Income Expense
Net loss
Profit Loss
Net loss per share, basic and diluted
Earnings Per Share Basic And Diluted
Weighted average common stock outstanding, basic and diluted
Weighted Average Number Of Share Outstanding Basic And Diluted
Statement Of Income And Comprehensive Income [Abstract]
Net loss
Other comprehensive (loss) income:
Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent [Abstract]
Unrealized (loss) gain on available-for-sale securities
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
Comprehensive loss
Comprehensive Income Net Of Tax Including Portion Attributable To Noncontrolling Interest
Pre-funded warrants issued during period, shares.
Pre-funded warrants issued during period, value.
Issuance of common stock to related party in connection with stock purchase agreement.
Issuance of common stock value to related party in connection with stock purchase agreement.
Vesting of restricted stock units.
Statement Of Stockholders Equity [Abstract]
Statement [Table]
Statement [Table]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock [Member]
Common Stock [Member]
Additional Paid In Capital [Member]
Additional Paid In Capital [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Accumulated Other Comprehensive Income [Member]
Accumulated Deficit [Member]
Retained Earnings [Member]
Statement [Line Items]
Statement [Line Items]
Beginning balance
Stockholders Equity Including Portion Attributable To Noncontrolling Interest
Beginning balance, units
Shares Outstanding
Equity-based compensation
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Sale of common stock, net of issuance costs
Stock Issued During Period Value New Issues
Sale of common stock, net of issuance costs, shares
Stock Issued During Period Shares New Issues
Issuance of common stock,to a related party, in connectionwith the Stock Purchase Agreement
Issuance Of Common Stock Value To Related Party In Connection With Stock Purchase Agreement
Issuance of common stock, to a related party, in connection with the Stock Purchase Agreement, shares
Issuance Of Common Stock To Related Party In Connection With Stock Purchase Agreement
Exercise of common stock options
Stock Issued During Period Value Stock Options Exercised
Exercise of common stock options, shares
Stock Issued During Period Shares Stock Options Exercised
Issuance of ESPP shares
Stock Issued During Period Value Employee Stock Purchase Plan
Issuance of ESPP shares, shares
Stock Issued During Period Shares Employee Stock Purchase Plans
Vesting of restricted stock units
Vesting Of Restricted Stock Units
Sale of pre-funded warrants
Pre Funded Warrants Issued During Period Value
Sale of pre-funded warrants, shares
Pre Funded Warrants Issued During Period Shares
Forfeiture of restricted stock awards
Stock Issued During Period Value Restricted Stock Award Forfeitures
Forfeiture of restricted stock awards units
Stock Issued During Period Shares Restricted Stock Award Forfeited
Unrealized gain (loss) on available-for-sale securities
Ending balance
Ending balance, units
Issuance costs
Adjustments To Additional Paid In Capital Stock Issued Issuance Costs
Proceeds from issuance of common stock to related party.
Employee stock purchases and withholdings.
Increase decrease in right of use asset and lease liability due to lease termination.
Statement Of Cash Flows [Abstract]
Operating activities:
Net Cash Provided By Used In Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Net amortization of premium/(discount) on available-for-sale securities
Accretion Amortization Of Discounts And Premiums Investments
Equity-based compensation expense
Share Based Compensation
Depreciation and amortization expense
Depreciation And Amortization
Loss on sale of property and equipment
Gain Loss On Sale Of Property Plant Equipment
Gain on lease termination
Gain Loss On Termination Of Lease
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Prepaid expenses and other current and non-current assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Accounts receivable - related party
Increase Decrease In Accounts Receivable Related Parties
Accounts payable
Increase Decrease In Accounts Payable
Accrued expenses and other current and non-current liabilities
Increase Decrease In Accrued Liabilities And Other Operating Liabilities
Deferred revenue - related party, current and non-current
Increase Decrease In Deferred Revenue
Net cash used in operating activities
Net Cash Provided By Used In Operating Activities
Investing activities:
Net Cash Provided By Used In Investing Activities [Abstract]
Purchases of property and equipment
Payments To Acquire Property Plant And Equipment
Proceeds from sales and maturities of available-for-sale securities
Payments For Proceeds From Availableforsale Securities Shortterm
Purchases of available-for-sale securities
Payments To Acquire Available For Sale Securities Debt
Net cash (used in) provided by investing activities
Net Cash Provided By Used In Investing Activities
Financing activities:
Net Cash Provided By Used In Financing Activities [Abstract]
Proceeds from the issuance of common stock to a related party in connection with the Stock Purchase Agreement
Proceeds From Issuance Of Common Stock To Related Party
Proceeds from issuance of common stock, net of issuance costs
Proceeds From Issuance Of Common Stock
Payment of offering costs
Payments Of Stock Issuance Costs
Proceeds from issuance of pre-funded warrants
Proceeds From Issuance Of Warrants
Proceeds for exercise of stock options
Proceeds From Stock Options Exercised
Employee stock purchases and withholdings
Employee Stock Purchases And Withholdings
Net cash provided by financing activities
Net Cash Provided By Used In Financing Activities
Net (decrease) increase in cash, cash equivalents and restricted cash
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Cash, cash equivalents, and restricted cash at beginning of period
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
Cash, cash equivalents, and restricted cash at end of period
Supplemental disclosure of non-cash investing and financing activities:
Cash Flow Noncash Investing And Financing Activities Disclosure [Abstract]
Decrease in ROU asset and lease liability due to lease termination
Increase Decrease In Right Of Use Asset And Lease Liability Due To Lease Termination
Property and equipment included in accounts payable and accruals
Capital Expenditures Incurred But Not Yet Paid
Accounting Policies [Abstract]
Nature of the Business and Basis of Presentation
Business Description And Basis Of Presentation [Text Block]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Collaborations.
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Collaborations
Collaborations [Text Block]
Fair Value Disclosures [Abstract]
Fair Value of Financial Assets and Liabilities
Fair Value Measurement Inputs Disclosure [Text Block]
Investments Debt And Equity Securities [Abstract]
Available-for-Sale Securities
Investments In Debt And Marketable Equity Securities And Certain Trading Assets Disclosure [Text Block]
Prepaid expenses and other current assets.
Deferred Costs Capitalized Prepaid And Other Assets Disclosure [Abstract]
Prepaid Expenses and Other Current Assets
Prepaid Expenses And Other Current Assets [Text Block]
Property Plant And Equipment [Abstract]
Property and Equipment
Property Plant And Equipment Disclosure [Text Block]
Payables And Accruals [Abstract]
Accrued Expenses
Accounts Payable Accrued Liabilities And Other Liabilities Disclosure Current [Text Block]
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Equity-Based Compensation
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
Operating and financing leases.
Leases [Abstract]
Leases
Operating And Financing Leases Disclosure [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments And Contingencies Disclosure [Text Block]
License Agreements
Collaborative Arrangement Disclosure [Text Block]
Earnings Per Share [Abstract]
Net Loss per Share
Earnings Per Share [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Compensation And Retirement Disclosure [Abstract]
Defined Contribution Plan
Defined Contribution Plan [Text Block]
Restructuring And Related Activities [Abstract]
Restructuring
Restructuring And Related Activities Disclosure [Text Block]
Use of Estimates
Use Of Estimates
Cash Equivalents
Cash And Cash Equivalents Policy [Text Block]
Restricted Cash
Cash And Cash Equivalents Restricted Cash And Cash Equivalents Policy
Available-for-Sale Securities
Marketable Securities Policy
Concentration of Credit Risk and of Significant Suppliers
Concentration Risk Credit Risk
Fair Value Measurements
Fair Value Of Financial Instruments Policy
Leases
Lessee Leases Policy [Text Block]
Property and Equipment
Property Plant And Equipment Policy [Text Block]
Impairment of Long-Lived Assets
Impairment Or Disposal Of Long Lived Assets Policy [Text Block]
Revenue Recognition
Revenue From Contract With Customer Policy [Text Block]
Research and Development Costs
Research And Development Expense Policy
Research contract costs and accruals.
Research Contract Costs and Accruals
Research Contract Costs And Accruals Policy [Text Block]
Patent Costs
Intangible Assets Finite Lived Policy
Equity-Based Compensation
Share Based Compensation Option And Incentive Plans Policy
Income Taxes
Income Tax Policy [Text Block]
Segment Data
Segment Reporting Policy Policy [Text Block]
Comprehensive Loss
Comprehensive Income Policy Policy [Text Block]
Net Loss per Share
Earnings Per Share Policy [Text Block]
Funding from charitable organizations.
Funding from Charitable Organizations
Funding From Charitable Organizations Policy [Text Block]
Contingencies
Commitments And Contingencies Policy [Text Block]
Recently Adopted Accounting Pronouncements
New Accounting Pronouncements Policy Policy [Text Block]
Related party transaction.
Related Party
Related Party Transaction Policy [Text Block]
Reconciliation Of Beginning And End Of Period Amounts From Cash Flow Statement To Balance Sheet Table [Text Block]
Reconciliation of Amounts From Cash Flow Statement to Balance Sheet
Reconciliation Of Beginning And End Of Period Amounts From Cash Flow Statement To Balance Sheet Table [Text Block]
Summary of Changes in Balances of Company's Related Party Collaboration Receivables and Contract Liabilities
Contract With Customer Asset And Liability Table [Text Block]
Summary of Assets and Liabilities Measured at Fair Value on Recurring Basis and Indicate Level of Fair Value Hierarchy Utilized
Fair Value Assets Measured On Recurring Basis [Text Block]
Schedule of Fair Value of Available-for-Sale Debt Securities by Type of Security
Debt Securities Available For Sale Table [Text Block]
Summary Estimated Fair Value and Amortized Cost of Available-for-Sale Securities by Contractual Maturity
Investments Classified By Contractual Maturity Date Table [Text Block]
Schedule of Prepaid Expenses and Other Current Assets
Deferred Costs Capitalized Prepaid And Other Assets Disclosure [Text Block]
Summary of Property and Equipment
Property Plant And Equipment [Text Block]
Accrued expenses and other current liabilities.
Summary of Accrued Expenses and Other Current Liabilities
Accrued Expenses And Other Current Liabilities Table [Text Block]
Summary of Stock Option Activity
Schedule Of Share Based Compensation Stock Options Activity Table [Text Block]
Assumptions for Measuring Fair Values of Stock Options
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block]
Summary of Restricted Stock Unit Activity
Schedule Of Share Based Compensation Restricted Stock Units Award Activity Table [Text Block]
Summary of Unvested Restricted Shares of Common Stock Activity
Schedule Of Sharebased Compensation Restricted Stock And Restricted Stock Units Activity Table [Text Block]
Schedule of Equity-based Compensation Expense
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Lessee lease liability maturity.
Future Minimum Payments for Operating and Finance Leases
Lessee Lease Liability Maturity Table [Text Block]
Supplemental disclosure of cash flow information related to leases and weighted average remaining lease term and discount rate...
Supplemental Disclosure of Cash Flow Information Related to Leases and Weighted Average Remaining Lease Term and Discount Rate
Supplemental Disclosure Of Cash Flow Information Related To Leases And Weighted Average Remaining Lease Term And Discount Rate Disclosures Table [Text Block]
Schedule of Basic and Diluted Net Loss per Share
Schedule Of Earnings Per Share Basic And Diluted Table [Text Block]
Schedule of Antidilutive Securities Excluded from Calculation of Diluted Net Loss per Share
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Schedule of Reconciliation of Income Taxes Computed by U.S. Federal Statutory Rate
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Schedule of Net Deferred Tax Assets
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Schedule of Total Amount Expected to be Incurred and Liability Related to Restructuring
Schedule Of Restructuring Reserve By Type Of Cost [Text Block]
Net loss
Accumulated deficit
Net cash used in operating activities
Cash and cash equivalents
Cash, cash equivalents and available-for-sale securities
Cash Cash Equivalents And Short Term Investments
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Long-Lived Tangible Asset
Property Plant And Equipment By Type [Axis]
Long-Lived Tangible Asset
Property Plant And Equipment Type [Domain]
Laboratory Equipment [Member]
Equipment [Member]
Computer Equipment [Member]
Computer Equipment [Member]
Computer Software [Member]
Software And Software Development Costs [Member]
Furniture and Office Equipment [Member]
Furniture And Fixtures [Member]
Leasehold Improvements [Member]
Leasehold Improvements [Member]
Accounting Standards Update
Adjustments For New Accounting Pronouncements [Axis]
Accounting Standards Update
Type Of Adoption [Member]
ASC Topic 606 [Member]
Accounting Standards Update201409 [Member]
Collaborative Arrangement and Arrangement Other than Collaborative
Type Of Arrangement [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Arrangements And Nonarrangement Transactions [Member]
Funding from charitable organizations.
Funding From Charitable Organizations [Member]
Funding From Charitable Organizations [Member]
Counterparty Name
Counterparty Name [Axis]
Counterparty Name
Repurchase Agreement Counterparty Name [Domain]
Ultragenyx
Ultragenyx [Member]
Ultragenyx [Member]
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement [Member]
Collaborative Arrangement Transaction With Party To Collaborative Arrangement [Member]
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Restricted cash deposit
Deposit Assets
Restricted cash noncurrent
Reconciliation of beginning and end of period amounts From cash flow statement to balance sheet.
Reconciliation Of Beginning And End Of Period Amounts From Cash Flow Statement To Balance Sheet [Abstract]
Cash and cash equivalents
Restricted cash, non-current
Cash and cash equivalents and restricted cash
Useful life of asset
Property Plant And Equipment Useful Life
Useful life of asset
Property Plant And Equipment Estimated Useful Lives
Change in accounting principle, accounting standards update, adopted
Change In Accounting Principle Accounting Standards Update Adopted
Income tax expense (benefit)
Income Tax Expense Benefit
Common stock shares issued warrant to purchase.
Agreement termination period.
Agreement written notice period.
Payment of exchange fees
Exchange Fees
Common stock shares issued warrant to purchase
Common Stock Shares Issued Warrant To Purchase
Common stock warrants exercise price per share
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1
Agreement termination period
Agreement Termination Period
Agreement written notice period
Agreement Written Notice Period
Milestone payments upon achievement of development milestone.
Milestone payments upon achievement of regulatory milestone.
Milestone payments upon achievement of net sales milestones.
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Statistical Measurement
Range [Axis]
Statistical Measurement
Range [Member]
Maximum [Member]
Maximum [Member]
Minimum [Member]
Minimum [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Milestone payments upon achievement of development milestone
Milestone Payments Upon Achievement Of Development Milestone
Milestone payments upon achievement of regulatory milestone
Milestone Payments Upon Achievement Of Regulatory Milestone
Milestone Payments upon achievement of net sales milestones
Milestone Payments Upon Achievement Of Net Sales Milestones
Percentage of option to fund of development cost.
Percentage of option to fund of development cost
Percentage Of Option To Fund Of Development Cost
Percentage of net income and net losses on net sales.
Percentage of net income and net losses on net sales
Percentage Of Net Income And Net Losses On Net Sales
Agreement termination notice period.
Agreement termination notice period
Agreement Termination Notice Period
Percentage of outstanding common stock.
Issued and sold shares of common stock
Common stock issued price per share
Shares Issued Price Per Share
Proceeds from issuance of common stock
Percentage of outstanding common stock
Percentage Of Outstanding Common Stock
Transaction price.
Proceeds from equity investment under stock purchase agreement
Proceeds From Sale Of Equity Method Investments
Transaction price
Transaction Price
Related party transaction, payment.
Related party revenue recognized
Revenue From Related Parties
Related party transaction, payment
Related Party Transaction Payment
Due from related parties
Due From Related Parties
Accounts receivable related parties additions.
Accounts receivable related parties deductions.
Related party collaboration receivable, Beginning balance
Related party collaboration receivable, Additions
Accounts Receivable Related Parties Additions
Related party collaboration receivable, Deductions
Accounts Receivable Related Parties Deductions
Related party collaboration receivable, Ending balance
Contract with customer liability additions.
Contract with customer liability deductions.
Deferred revenue, Beginning balance
Contract With Customer Liability
Deferred revenue, Additions
Contract With Customer Liability Additions
Deferred revenue, Deductions
Contract With Customer Liability Deductions
Deferred revenue, Ending balance
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Level 1 [Member]
Fair Value Inputs Level1 [Member]
Level 2 [Member]
Fair Value Inputs Level2 [Member]
Level 3 [Member]
Fair Value Inputs Level3 [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets:
Assets Fair Value Disclosure [Abstract]
Cash equivalents
Cash Equivalents At Carrying Value
Available-for-sale securities
Available For Sale Securities Debt Securities
Assets Fair Value Disclosure
Assets Fair Value Disclosure
Fair value, assets, level 1 to level 2 transfers, amount
Fair Value Assets Level1 To Level2 Transfers Amount
Fair value, assets, level 2 to level 1 transfers, amount
Fair Value Assets Level2 To Level1 Transfers Amount
Fair value, assets, transfers into level 3, amount
Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Asset Transfers Into Level3
Fair value, assets, transfers out of level 3, amount
Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Asset Transfers Out Of Level3
Debt Securities Available For Sale [Table]
Debt Securities Available For Sale [Table]
Investment Type
Investment Type [Axis]
Investments
Investment Type Categorization [Member]
Treasury bill.
Treasury Bill [Member]
Treasury Bill [Member]
Corporate Bond Securities [Member]
Corporate Bond Securities [Member]
Commercial Paper [Member]
Commercial Paper [Member]
Debt Securities, Available-for-sale [Line Items]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost
Available For Sale Debt Securities Amortized Cost Basis
Gross Unrealized Gain
Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax
Gross Unrealized Loss
Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax
Fair Value
Due in one year or less, amortized cost
Available For Sale Securities Debt Maturities Next Rolling Twelve Months Amortized Cost Basis
Due in one year or less, fair value
Available For Sale Securities Debt Maturities Next Rolling Twelve Months Fair Value
Total available-for-sale securities, fair value
Available For Sale Securities Weighted Average Maturity period
Available-for-sale securities average maturity period
Available For Sale Securities Weighted Average Maturity Period
Prepaid research and development expenses, current.
Prepaid expenses and other assets, miscellaneous, current.
Prepaid research and development expenses
Prepaid Research And Development Expenses Current
Prepaid expenses and other assets
Prepaid Expense And Other Assets Miscellaneous Current
Prepaid expenses and other current assets
Schedule Of Property Plant And Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Furniture and Fixtures [Member]
Construction in Progress [Member]
Construction In Progress [Member]
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Property and equipment, gross
Property Plant And Equipment Gross
Less accumulated depreciation
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Property and equipment, net
Depreciation expense
Depreciation
Accrued Liabilities And Other Liabilities [Abstract]
Accrued Expenses And Other Current Liabilities [Line Items]
Accrued Expenses And Other Current Liabilities [Table]
Accrued Expenses And Other Current Liabilities [Table]
Accrued Expenses And Other Current Liabilities [Table]
Balance Sheet Location
Balance Sheet Location [Axis]
Balance Sheet Location
Balance Sheet Location [Domain]
Accrued research and development.
Accrued Research and Development [Member]
Accrued Research And Development [Member]
Accrued compensation.
Accrued Compensation [Member]
Accrued Compensation [Member]
Accrued other.
Accrued Other [Member]
Accrued Expenses And Other [Member]
Accrued Expenses And Other Current Liabilities [Line Items]
Accrued Expenses And Other Current Liabilities [Line Items]
Accrued expenses and other current liabilities
Employee Service Share Based Compensation Aggregate Disclosures [Abstract]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
2018 Omnibus Incentive Plan.
2018 Omnibus Incentive Plan [Member]
Two Thousand And Eighteen Omnibus Incentive Plan [Member]
2020 equity incentive plan.
2020 Equity Incentive Plan [Member]
Two Thousand And Twenty Equity Incentive Plan [Member]
Two thousand and twenty one employee stock purchase plan.
2021 Employee Stock Purchase Plan [Member]
Two Thousand And Twenty One Employee Stock Purchase Plan [Member]
Award Type
Award Type [Axis]
Award Type
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Stock Option [Member]
Employee Stock Option [Member]
'Restricted Stock Units (RSUs) [Member]
Restricted Stock Units R S U [Member]
Restricted Stock [Member]
Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares authorized for common stock for equity awards
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Authorized
Number of additional shares authorized for common stock for equity awards
Share Based Compensation Arrangement By Share Based Payment Award Number Of Additional Shares Authorized
Number of shares available for future issuance
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
Number of Options
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Roll Forward
Outstanding at December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Exercised
Forfeitures
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
Outstanding at December 31, 2021
Vested and expected to vest as of December 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Number
Exercisable at December 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Weighted Average Exercise Price
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Rollforward
Outstanding at December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Exercised
Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
Forfeitures
Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
Outstanding at December 31, 2021
Vested and expected to vest as of December 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Exercise Price
Exercisable at December 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Remaining Contractual Life (in years)
Share Based Compensation Arrangement By Share Based Payment Award Options Additional Disclosures [Abstract]
Outstanding
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Vested and expected to vest as of December 31, 2021
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Remaining Contractual Term1
Exercisable at December 31, 2021
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
Unrecognized equity-based compensation cost related to stock option
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
Stock options outstanding, weighted average recognition period
Stock options outstanding, intrinsic value
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Intrinsic value of stock options exercisable
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Intrinsic value of stock options exercised
Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
Expected volatility, Minimum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Minimum
Expected volatility, Maximum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Maximum
Expected dividends
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Expected term (in years)
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Risk-free rate, Minimum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Minimum
Risk-free rate, Maximum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Maximum
Weighted average fair value of options to purchase common stock granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Vesting period
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
Share based compensation arrangement by share based payment award equity instruments other than options unvested number.
Units
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Roll Forward
Unvested at December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period
Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Forfeitures
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited In Period
Outstanding at December 31, 2021
Unvested as of December 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Unvested Number
Share based compensation arrangement by share based payment award equity instruments other than options unvested weighted average grant date fair value.
Weighted-Average Grant Date Fair Value
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value Roll Forward
Unvested at December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value
Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value
Forfeitures
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeitures Weighted Average Grant Date Fair Value
Outstanding at December 31, 2021
Unvested as of December 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Unvested Weighted Average Grant Date Fair Value
Unrecognized equity-based compensation
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Share Based Awards Other Than Options
Unrecognized equity-based compensation cost, weighted average period
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Releases
Forfeitures
Releases
Aggregate intrinsic value of restricted common units vested
Sharebased Compensation Arrangement By Sharebased Payment Award Equity Instruments Other Than Options Aggregate Intrinsic Value Vested
Share Based Compensation Allocation And Classification In Financial Statements [Abstract]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Research and Development Expenses [Member]
Research And Development Expense [Member]
General and Administrative Expenses [Member]
General And Administrative Expense [Member]
Restructuring Expense [Member]
Restructuring Charges [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Stock-based compensation expense
Allocated Share Based Compensation Expense
Commitment And Contingencies [Line Items]
Commitment And Contingencies [Table]
Commitment And Contingencies [Table]
Commitment And Contingencies [Table]
Name of Property
Real Estate And Accumulated Depreciation Description Of Property [Axis]
Name of Property
Real Estate And Accumulated Depreciation Name Of Property [Domain]
Lab space.
Lab Space [Member]
Lab Space [Member]
Geographical
Statement Geographical [Axis]
Geographical
Segment Geographical [Domain]
Cambridge, Massachusetts [Member]
MASSACHUSETTS
Office space.
Office Space [Member]
Office Space [Member]
Lab Equipment [Member]
MOROCCO
MOROCCO
Office laboratory.
Office laboratory [Member]
Office Laboratory [Member]
Hood Park LLC.
Hood Park LLC [Member]
Hood Park L L C [Member]
Commitment And Contingencies [Line Items]
Commitment And Contingencies [Line Items]
Area of lease agreement
Area Of Real Estate Property
Lease term
Lessee Operating Lease Term Of Contract
Lessee, Operating Lease, Existence of Option to Extend [true false]
Lessee Operating Lease Existence Of Option To Extend
Lease renewal term
Lessee Operating Lease Renewal Term
Future minimum rent commitment
Lessee Operating Lease Liability Payments Due
Lease expiration month and year.
Lease expiration period
Lease Expiration Month And Year
Lease term of contract
Lessee Finance Lease Term Of Contract1
Future minimum lease commitment
Finance Lease Liability Payments Due
Lease liability
Operating Lease Liability
Operating lease, monthly payments.
Operating lease payments annual escalation percentage.
Construction allowance.
Construction costs.
Lease description
Lessee Operating Lease Description
Operating lease, monthly payments
Operating Lease Monthly Payments
Operating lease payments annual escalation percentage
Operating Lease Payments Annual Escalation Percentage
Construction allowance
Construction Allowance
Letter of credit amount
Letters Of Credit Outstanding Amount
Construction costs
Construction Costs
Finance Leases
Finance Lease Liabilities Payments Due [Abstract]
2022
Finance Lease Liability Payments Due Next Twelve Months
2023
Finance Lease Liability Payments Due Year Two
2024
Finance Lease Liability Payments Due Year Three
2025
Finance Lease Liability Payments Due Year Four
Thereafter
Finance Lease Liability Payments Due After Year Five
Total future minimum lease payments
Less: Imputed Interest
Finance Lease Liability Undiscounted Excess Amount
Total Lease Liabilities
Finance Lease Liability
Operating Leases
Operating Lease Liabilities Payments Due [Abstract]
2022
Lessee Operating Lease Liability Payments Due Next Twelve Months
2023
Lessee Operating Lease Liability Payments Due Year Two
2024
Lessee Operating Lease Liability Payments Due Year Three
2025
Lessee Operating Lease Liability Payments Due Year Four
Thereafter
Lessee Operating Lease Liability Payments Due After Year Five
Total future minimum lease payments
Less: Imputed Interest
Lessee Operating Lease Liability Undiscounted Excess Amount
Rent expense
Lease Cost
Operating and finance lease payments.
Other information.
Weighted-average remaining lease term.
Weighted-average discount rate.
Other information
Other Information [Abstract]
Cash paid for amounts included in the measurement of lease liabilities
Operating And Finance Lease Payments
Operating lease liabilities arising from obtaining right-of-use-assets
Right Of Use Asset Obtained In Exchange For Operating Lease Liability
Finance lease liabilities arising from obtaining right-of-use assets
Right Of Use Asset Obtained In Exchange For Finance Lease Liability
Weighted-average remaining lease term (in years)
Weighted Average Remaining Lease Term [Abstract]
Operating lease
Operating Lease Weighted Average Remaining Lease Term1
Finance lease
Finance Lease Weighted Average Remaining Lease Term1
Weighted-average discount rate
Weighted Average Discount Rate [Abstract]
Operating lease
Operating Lease Weighted Average Discount Rate Percent
Finance lease
Finance Lease Weighted Average Discount Rate Percent
Lease Contractual Term
Lease Contractual Term [Axis]
Lease Contractual Term
Lease Contractual Term [Domain]
Office and laboratory lease.
Office and Laboratory Lease [Member]
Office And Laboratory Lease [Member]
Letter of credit outstanding amount
Milestone payment upon achievement of certain milestones.
Milestone amount payable in connection with agreement.
Maximum milestone payment to be made.
Indefinite-lived Intangible Assets
Indefinite Lived Intangible Assets By Major Class [Axis]
Indefinite-lived Intangible Assets, Major Class Name
Indefinite Lived Intangible Assets Major Class Name [Domain]
University of Washington license agreement
University of Washington [Member]
University Of Washington License Agreement [Member]
University of Missouri License Agreement
University of Missouri [Member]
University Of Missouri License Agreement [Member]
Scenario
Statement Scenario [Axis]
Scenario
Scenario Unspecified [Domain]
Forecast
Scenario Forecast [Member]
Subsequent Event Type
Subsequent Event Type [Axis]
Subsequent Event Type
Subsequent Event Type [Domain]
Subsequent Event [Member]
Subsequent Event [Member]
University of Michigan license agreement member.
University of Michigan [Member]
University Of Michigan License Agreement [Member]
President and Fellows of Harvard College.
President and Fellows of Harvard College [Member]
President And Fellows Of Harvard College [Member]
Harvard college license agreements member.
Harvard College [Member]
Harvard College License Agreements [Member]
Maximum milestone payment to be made
Maximum Milestone Payment To Be Made
Milestone payment upon achievement of certain milestones
Milestone Payment Upon Achievement Of Certain Milestones
Amount payable in connection with execution of collaboration agreement
Milestone Amount Payable In Connection With Agreement
Research and development expense
Milestone payment.
Milestone payment
Milestone Payment
license agreement initial term.
License agreement renewal term.
License agreement initial term
License Agreement Initial Term
License agreement renewal term
License Agreement Renewal Term
Schedule Of Earnings Per Share Basic By Common Class [Table]
Schedule Of Earnings Per Share Basic By Common Class [Table]
Pre-funded warrants.
Pre-Funded Warrants [Member]
Pre Funded Warrants [Member]
Earnings Per Share Basic [Line Items]
Earnings Per Share Basic [Line Items]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Options to Purchase Shares of Common Stock [Member]
Unvested Restricted Stock Units [Member]
Unvested common stock.
Unvested Shares of Common Stock [Member]
Unvested Common Stock [Member]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Common stock equivalents excluded from calculation of diluted net loss per share
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Income Taxes [Line Items]
Income Taxes [Table]
Income Taxes [Table]
Income Taxes [Table]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
Domestic Tax Authority [Member]
Domestic Country [Member]
State and Local Jurisdiction [Member]
State And Local Jurisdiction [Member]
Income Taxes [Line Items]
Income Taxes [Line Items]
Effective Income Tax Rate Reconciliation Permanent Differences
Effective income tax rate reconciliation change in deferred tax rate.
Effective income tax rate reconciliation share based compensation cancelations percent.
Income tax computed at federal statutory tax rate
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
State taxes, net of federal benefit
Effective Income Tax Rate Reconciliation State And Local Income Taxes
Permanent differences
Effective Income Tax Rate Reconciliation Permanent Differences
Tax credits
Effective Income Tax Rate Reconciliation Tax Credits
Change in deferred tax rate
Effective Income Tax Rate Reconciliation Change In Deferred Tax Rate
Stock compensation cancelations
Effective Income Tax Rate Reconciliation Share Based Compensation Cancelations Percent
Other
Effective Income Tax Rate Reconciliation Other Adjustments
Valuation allowance
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
Total
Effective Income Tax Rate Continuing Operations
Deferred tax assets tax deferred accrued expense.
Deferred tax assets tax depreciation.
Deferred tax liabilities right of use asset.
Deferred tax liabilities depreciation.
Components Of Deferred Tax Assets And Liabilities [Abstract]
Deferred tax assets:
Components Of Deferred Tax Assets [Abstract]
Tax loss carryforwards
Deferred Tax Assets Operating Loss Carryforwards
Tax credit carryforwards
Deferred Tax Assets Tax Credit Carryforwards
Deferred expenses
Deferred Tax Assets Tax Deferred Expense
Accrued expenses
Deferred Tax Assets Tax Deferred Accrued Expense
Stock compensation
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
Intangible assets
Deferred Tax Assets Goodwill And Intangible Assets
Depreciation
Deferred Tax Assets Tax Depreciation
Other
Deferred Tax Assets Other
Total deferred tax assets
Deferred Tax Assets Gross
Valuation allowance
Deferred Tax Assets Valuation Allowance
Deferred tax liabilities:
Components Of Deferred Tax Liabilities [Abstract]
Right of use asset
Deferred Tax Liabilities Right Of Use Asset
Depreciation
Deferred Tax Liabilities Depreciation
Total deferred tax liabilities
Deferred Tax Liabilities
Net deferred taxes
Deferred Tax Assets Liabilities Net
Operating loss carryforwards, expiration period.
Tax credit carryforwards, expiration period.
Percentage of annual taxable income.
Net operating loss carryforwards
Operating Loss Carryforwards
Operating loss carryforwards, expiration period
Operating Loss Carryforwards Expiration Period
Tax credits carryforwards
Tax Credit Carryforward Amount
Tax credit carryforwards, expiration period
Tax Credit Carryforwards Expiration Period
Uncertain tax position
Liability For Uncertain Tax Positions Current
Percentage of annual deduction equal to annual taxable income
Percentage Of Annual Taxable Income
Unrecognized tax benefits
Unrecognized Tax Benefits
Tax interest and penalties
Income Tax Examination Penalties And Interest Expense
Company's contribution to the plan
Defined Contribution Plan Employer Discretionary Contribution Amount
Restructuring Costs [Abstract]
Restructuring charges were paid
Payments For Restructuring
Number of headcount reduced, percentage
Restructuring And Related Cost Number Of Positions Eliminated Period Percent
Restructuring charges related to severance payment and other employee-related costs
Severance Costs1
Adjustment of Carrying amount (including both current and noncurrent portions of the accrual) as of the balance sheet date pertaining to a specified type of cost associated with exit from or disposal of business activities or restructuring pursuant to a duly authorized plan.
Restructuring Costs Line items.
Restructuring costs table.
Restructuring Costs [Table]
Restructuring Costs [Table]
Restructuring Type
Restructuring Cost And Reserve [Axis]
Type of Restructuring
Type Of Restructuring [Domain]
One-Time Employee Termination Benefits [Member]
One Time Termination Benefits [Member]
Restructuring Costs [Line Items]
Restructuring Costs [Line Items]
Accrued restructuring costs, beginning balance
Restructuring Reserve Adjustment
Restructuring charges incurred during the period
Amounts paid during the period
Accrued restructuring costs, ending balance